eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
Security Boulevard

GitHub Actions Supply Chain Attack: Trivy Breach & Workflow

Breakdown of the Trivy GitHub Actions attack, including workflow misconfigurations, token theft, and supply chain exposure.
Nature

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

After the first complete sequence of a human genome is obtained, the next challenge will be to discover and understand the function and variation of genes and, ultimately, to understand how such ...
Beirut Time

Mapping convergent regulators of melanoma drug resistance by PerturbFate

A375, HEK293T, Sk-Mel-3 and Sk-Mel-24 cell lines were obtained from the American Type Culture Collection. A375 and HEK293T cells were maintained in ...